Indapamide: How It Works, Dosing, and Side Effects

Indapamide is a blood pressure pill many doctors use when thiazide diuretics aren't ideal. It lowers blood pressure by helping your kidneys remove extra salt and water, and it also relaxes blood vessels. People like it because it can work at low doses with fewer metabolic effects than some older diuretics.

Who should consider it? If you have high blood pressure, especially with swelling or heart failure signs, indapamide may help. Older adults and people with salt-sensitive hypertension often respond well. Your doctor will pick it based on your other health issues and medications.

How to take indapamide

Indapamide usually comes as a tablet taken once a day, often in the morning. Take it with or without food, but try to take it the same time each day. Stick to the prescribed dose—don’t cut or double doses. If you miss one, take it when you remember unless it’s almost time for the next dose; then skip the missed one.

Regular blood pressure checks matter. Your doctor may also order blood tests to check kidney function, sodium, and potassium levels within a few weeks of starting. Bring a list of all your medicines, including supplements, because indapamide can interact with other drugs.

Common side effects & what to watch

Some people notice dizziness, especially when standing up quickly, because indapamide lowers blood pressure. Low potassium or sodium can happen and cause weakness, cramps, or irregular heartbeat. Less often you might see increased urination, skin reactions, or gout flare-ups.

Serious reactions are rare but worth knowing: extreme lightheadedness, fainting, fast or uneven heartbeat, severe muscle pain, or signs of very low sodium like confusion. If any of these happen, seek medical help immediately.

Drug interactions can raise risk. Don't mix indapamide with potassium-sparing diuretics or supplements unless your doctor advises it. Some blood pressure drugs, lithium, and certain diabetes meds may need dose changes or closer monitoring. If you take NSAIDs regularly, tell your doctor because they can blunt diuretics’ effects.

Pregnancy and breastfeeding need caution—indapamide is usually avoided or used only if clearly needed. If you have severe kidney disease, your doctor may choose a different medicine. Always discuss risks and benefits openly.

Practical tips: weigh yourself weekly to watch fluid changes, carry a list of medicines, and stay hydrated but avoid extra salt. If you feel dizzy, stand up slowly and ask for a check of your blood pressure while sitting and standing.

Want more specifics? Ask your prescriber about expected blood pressure targets, how long before you see results (often a few weeks), and when to repeat labs. That keeps things simple and safe while you get the most from indapamide.

If you’re switching from another diuretic, your doctor will likely taper or adjust doses and schedule more labs. Keep a symptom diary for the first month to track dizziness, cramps, or mood changes. Pharmacy pharmacists can answer storage, refill, and insurance questions if you call before a refill runs out.