Erectile dysfunction medication: what works, what to watch for

Worried about ED and confused by all the drug names? You’re not alone. There are a few main medicines that actually help most men, and knowing how they differ makes a big difference in safety and results. This page breaks down the basics, gives actionable tips on dosing and side effects, and explains how to buy safely online.

Quick drug differences

PDE5 inhibitors are the main class. Sildenafil (Viagra) usually works within 30–60 minutes and is best taken on an empty stomach. Tadalafil (Cialis) can last up to 36 hours—good if you want more spontaneity. Avanafil works faster for many men (often 15–30 minutes). Vardenafil is another option with a profile similar to sildenafil. The “Classic Pack” you may see online is just sildenafil plus tadalafil options bundled for convenience.

Dosage varies by drug and by person. Start low, follow your prescriber’s advice, and don’t double doses. If you find a medicine isn’t working, talk to your doctor instead of increasing the dose yourself.

Safety, interactions, and side effects

The biggest red flag: nitrates. If you take nitroglycerin or other nitrates for heart pain, PDE5 drugs can dangerously drop your blood pressure. Also be cautious with alpha-blockers for prostate issues; your doctor can space doses safely. Heavy alcohol and large meals can blunt sildenafil’s effect. Grapefruit can raise levels of some ED drugs because of CYP3A4 interactions—avoid it if you’re unsure.

Common side effects are headache, flushing, nasal congestion, and mild upset stomach. Vision changes or sudden hearing loss are rare but serious—seek help immediately. If you experience chest pain after taking a dose, get emergency care.

People with uncontrolled heart disease, low blood pressure, or certain retinal conditions should not take these medicines without a full medical check.

Many men ask whether ED meds affect prostate health or fertility. There’s some research on sildenafil and prostate symptoms, but don’t use ED drugs as a prostate treatment without medical advice. If fertility is a concern, mention it to your provider.

Want to try alternatives? Lifestyle changes—losing weight, quitting smoking, improving sleep, cutting back on alcohol—often help. Counseling helps when stress or relationship issues trigger ED.

Thinking of buying online? Make sure the pharmacy requires a prescription, shows a physical address and contact info, and has clear policies. Avoid sites offering controlled drugs without a prescription. Check reviews, authorized pharmacy directories, and, if needed, ask your pharmacist to verify the vendor.

Finally, don’t treat ED alone. A short chat with your doctor or a qualified telehealth provider can uncover causes like low testosterone, medications, or cardiovascular risks and help you pick the safest, most effective option.